Developing and scaling up fast-dissolving electrospun formulations based on poly(vinylpyrrolidone) and ketoprofen

Poly(vinyl pyrrolidone) (PVP) electrospun fibers loaded with ketoprofen were fabricated in this work as potential fast dissolving drug delivery systems (DDSs) for oral delivery. By changing the processing parameters and collector geometry it was possible to increase throughput rate from 1 20 mL/h. The all took shape of cylinders had smooth surfaces. They comprise amorphous solid dispersions drug-in-polymer, very high encapsulation efficiencies (100%). With a low loading (9.09% w/w) materials could disintegrate quickly accelerate dissolution profile under non-sink conditions representative cavity. However, at higher loadings (23.08% w/w), benefit is no longer realized, indicating that there maximum above which dissolution-enhancing properties form hydrophilic PVP carrier cease be effective. After storage ambient (19–21 °C, relative humidity 30–40%) 4 weeks, formulations remained amorphous, significant changes their release properties. Very similar behaviour terms stability seen regardless used fiber fabrication, showing rapidly produce large amounts high-performing material.